Glycoside hydrolase family 83

Hemagglutinin-neuraminidase
Structure of the sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase.[1]
Identifiers
Symbol HN
Pfam PF00423
Pfam clan CL0434
InterPro IPR000665
SCOP 1usr

In molecular biology, glycoside hydrolase family 83 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[2][3][4] This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site,[5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. [6]

Glycoside hydrolase family 83 CAZY GH_83 includes enzymes with neuraminidase EC 3.2.1. activity.[7]

References

  1. ^ Zaitsev V, von Itzstein M, Groves D, et al. (April 2004). "Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion". J. Virol. 78 (7): 3733–41. doi:10.1128/JVI.78.7.3733-3741.2004. PMC 371092. PMID 15016893. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=371092. 
  2. ^ Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090–7094. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41477. 
  3. ^ Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853–859. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779. 
  4. ^ Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.
  5. ^ Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.
  6. ^ CAZypedia, an online encyclopedia of carbohydrate-active enzymes.
  7. ^ Yuan P, Thompson TB, Wurzburg BA, Paterson RG, Lamb RA, Jardetzky TS (2005). "Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose.". Structure 13 (5): 803–15. doi:10.1016/j.str.2005.02.019. PMID 15893670. http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15893670.